How many U.S. vice presidents have resigned from office?

Two U.S. vice presidents have resigned from office.

John Calhoun resigned in a policy dispute with the president, and Spiro Agnew resigned after it was discovered he’d been taking bribes.

Spiro Theodore Agnew was the 39th Vice President of the United States, serving under President Richard Nixon.

Agnew was under investigation by the United States Attorney’s office on charges of extortion, tax fraud, bribery and conspiracy in 1973, and he was formally charged with having accepted bribes totaling more than $100,000.

Agnew is the only U.S. Vice President in history to resign because of criminal charges.